Simon C C Lucas

15PUBLICATIONS
44CO-AUTHORS
Biomolecular modelling and designCharacterisation of biological macromoleculesChemical engineering designMolecular targetsBiologically active molecules
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Publications (15)

|Jul 13, 2026
X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1).

|Dec 23, 2025
Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool.

J Henry Blackwell, Simon C C Lucas, Giovanni Battocchio

|Aug 20, 2025
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.

Simon C C Lucas, Alexander G Milbradt, Jason Breed

|Jul 30, 2025
Modular Synthetic Platform for the Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery.

Andres R Gomez-Angel, Hanna F Klein, Stephen Y Yao

|Jun 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.

Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas

|Apr 16, 2025
Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel-Lindau Tumor Suppressor Protein (VHL).

Simon C C Lucas, Yong Xu, Sarah Hewitt

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Frequent Collaborators

3 joint publications

Jennifer E Nelson

3 joint publications

Sylvain Demanze

3 joint publications

Adeline Palisse

3 joint publications

Michelle L Lamb