Frederik Rombouts

12PUBLICATIONS
16CO-AUTHORS
Biomolecular modelling and designCheminformatics and quantitative structure-activity relationshipsOrganic chemical synthesisBiomaterialsBiologically active molecules
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Publications (12)

|Aug 18, 2025
In Pursuit of Best-in-Class MCL-1 Inhibitors: Discovery of Highly Potent 1,4-Indoyl Macrocycles with Favorable Physicochemical Properties.

Ingrid Adriana Velter, William Lento, Aldo Peschiulli

|Jan 21, 2022
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Aldo Peschiulli, Daniel Oehlrich, Michiel Van Gool

|Oct 18, 2021
Expedient Access to Cyanated N-Heterocycles by Direct Flow-Electrochemical C(sp2 )-H Activation.

Mary-Ambre Carvalho, Samuël Demin, Carolina Martinez-Lamenca

|Sep 23, 2021
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.

Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada

|Sep 23, 2021
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

Frederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander

|Mar 15, 2021
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano

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Frequent Collaborators

6 joint publications

Harrie J M Gijsen

4 joint publications

Andrés A Trabanco

4 joint publications

Ken-Ichi Kusakabe

3 joint publications

Daniel Oehlrich