Thilo Focken

5PUBLICATIONS
8CO-AUTHORS
Neurology and neuromuscular diseasesCheminformatics and quantitative structure-activity relationships
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Publications (5)

|Feb 15, 2024
Molecular Pharmacology of Selective Na<sub>V</sub>1.6 and Dual Na<sub>V</sub>1.6/Na<sub>V</sub>1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.

Samuel J Goodchild, Noah Gregory Shuart, Aaron D Williams

|Mar 08, 2021
Discovery of Acyl-sulfonamide Na<sub>v</sub>1.7 Inhibitors GDC-0276 and GDC-0310.

Brian S Safina, Steven J McKerrall, Shaoyi Sun

|Sep 19, 2019
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Thilo Focken, Kristen Burford, Michael E Grimwood

|Dec 01, 2018
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na<sub>V</sub>) 1.7 with Potent Analgesic Activity.

Shaoyi Sun, Qi Jia, Alla Y Zenova

|May 09, 2018
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa<sub>V</sub>1.7 Inhibitors for the Treatment of Pain.

Thilo Focken, Sultan Chowdhury, Alla Zenova

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Frequent Collaborators

3 joint publications

Christoph M Dehnhardt

2 joint publications

Brian S Safina

1 joint publications

Benjamin D Sellers

1 joint publications

Steven J McKerrall