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Ian R Outhwaite

9PUBLICATIONS

26CO-AUTHORS

Molecular targetsCheminformatics and quantitative structure-activity relationshipsSignal transductionProteins and peptidesMedicine, nursing and health curriculum and pedagogy

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Publications (9)

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|Jul 31, 2024

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.

Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite

|Jan 31, 2024

Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo.

Daniel P Radin, Sophie Shifman, Ian R Outhwaite

|Dec 04, 2023

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting.

Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger

|Oct 18, 2023

Probing conformational dynamics to understand kinase inhibition.

Ian R Outhwaite, Markus A Seeliger

|Feb 16, 2023

Allosteric regulation and inhibition of protein kinases.

Victoria R Mingione, YiTing Paung, Ian R Outhwaite

|Jan 30, 2023

Death by a Thousand Cuts â€" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology.

Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger

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Frequent Collaborators

6 joint publications

Markus A Seeliger

2 joint publications

Aziz M Rangwala

2 joint publications

John D Chodera

1 joint publications

Stephen Barstow Long

1 joint publications

Hannah E Phillips

1 joint publications

Rebecca B Jennings

1 joint publications

Neil P Shah

1 joint publications

Mansi Chandra

1 joint publications

Victoria Ende

1 joint publications

Alexander A Peterson

Frequent Collaborators

6 joint publications

Markus A Seeliger

2 joint publications

Aziz M Rangwala

2 joint publications

John D Chodera

1 joint publications

Stephen Barstow Long

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