Jeff Smaill

10PUBLICATIONS
38CO-AUTHORS
Metabolic medicineNanophotonicsMolecular targetsWastewater treatment processesCancer therapy (excl. chemotherapy and radiation therapy)
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Publications (10)

|Aug 12, 2026
A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes.

|Jun 27, 2024
Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623.

Abigail V Sharrock, Jeff S Mumm, Elsie M Williams

|Feb 26, 2022
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.

Amir Ashoorzadeh, Alexandra M Mowday, Christopher P Guise

|Dec 28, 2021
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.

Maria R Abbattista, Amir Ashoorzadeh, Christopher P Guise

|Nov 27, 2021
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit.

Dean C Singleton, Alexandra M Mowday, Chris P Guise

|Oct 09, 2021
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.

Alexander M A van der Wiel, Victoria Jackson-Patel, Raymon Niemans

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Frequent Collaborators

9 joint publications

Adam V Patterson

5 joint publications

Alexandra M Mowday

4 joint publications

David F Ackerley

3 joint publications

Amir Ashoorzadeh