James Irving

21PUBLICATIONS
66CO-AUTHORS
BiomaterialsFood engineeringPolymerisation mechanismsOccupational epidemiologyPolymers and plastics
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Publications (21)

|May 01, 2026
BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease.

|Nov 13, 2025
The mechanism of pathogenic α1-antitrypsin aggregation in the human liver.

Ibrahim Aldobiyan, Emma L K Elliston, Narinder Heyer-Chauhan

|May 07, 2025
High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.

Sarah M Lowen, Christopher A Waudby, Alistair M Jagger

|Mar 24, 2025
Top-Down Ion Mobility Mass Spectrometry Reveals a Disease Associated Conformational Ensemble of Alpha-1-antitrypsin.

Sarah Vickers, Ibrahim Aldobiyan, Sarah M Lowen

|Jan 08, 2025
Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.

Roberto Gangemi, Mattia Bignotti, Andrea Denardo

|Mar 25, 2024
A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.

Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar

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Frequent Collaborators

10 joint publications

David A Lomas

7 joint publications

Annamaria Fra

5 joint publications

Riccardo Ronzoni

4 joint publications

Elena Miranda