Related Experiment Videos
Primary eyelid plasmacytoma
L Olivieri1, M Di Ianni, M Giansanti
1Department of Clinical and Experimental Medicine, Hematology and Immunology Section, University of Perugia, Perugia, Italy.
Insights
This study details a rare eyelid plasmacytoma case. Surgical removal was successful, with no signs of systemic disease or need for further treatment.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Plasmacytomas are rare plasma cell tumors that can occur in various locations.
- Eyelid involvement is uncommon, presenting diagnostic and therapeutic challenges.
Observation:
- A patient presented with a superficial 10x7 mm lesion on the upper left eyelid.
- Histological and immunohistochemical analysis revealed plasmacytoma with sub-epidermic plasma cell infiltrates.
Findings:
- Immunoperoxidase staining confirmed plasmacytoma by showing strong positivity for intracytoplasmic kappa light chains.
- Bone marrow biopsy, aspirate, and skeletal surveys ruled out systemic disease, including multiple myeloma or osteoporosis.
Implications:
- This case highlights the importance of thorough evaluation for eyelid lesions suspicious for plasmacytoma.
- Successful surgical excision without radiotherapy suggests a favorable prognosis for localized eyelid plasmacytoma.
Abstract:
We report a case of eyelid plasmacytoma. The patient presented with a superficial lesion on the upper left eyelid, 10x7 mm in size. Histological and immunohistochemical findings were indicative of plasmacytoma with slightly abnormal sub-epidermic plasma cell infiltrates. Immunoperoxidase staining was strongly positive for intracytoplasmic kappa light chains. No infiltration by atypical plasma cells could be documented in the bone marrow biopsy and aspirate. Skeletal survey showed no osteolytic lesions or osteoporosis. The tumor on the left eyelid was surgically removed. No radiotherapy was administered.