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Immunological assessment in patients of leukaemia
V S Ghalaut1, P S Ghalaut, S Kharb
1Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana.
Indian Journal of Pathology & Microbiology
|December 29, 2000
Insights
Leukemia patients did not show immune deficiency. Both delayed hypersensitivity and humoral responses remained normal, even during remission, indicating preserved immune function in these leukemia cases.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- Leukemia is a cancer of blood-forming tissues.
- Immune system function can be affected by leukemia.
- Assessing immune status in leukemia patients is crucial for understanding disease progression and treatment efficacy.
Purpose of the Study:
- To evaluate the cellular and humoral immune responses in leukemia patients.
- To determine if leukemia patients exhibit anergy or immunodeficiency.
- To assess immune response during remission in leukemia patients.
Main Methods:
- Delayed cutaneous hypersensitivity (DNCB test) was used to assess cellular immunity.
- Humoral immune response was evaluated by quantifying immunoglobulin levels.
- The study included 20 cases of leukemia.
Main Results:
- No cases of leukemia were found to be anergic or immunodeficient.
- Both delayed cutaneous hypersensitivity and humoral responses were normal in the studied patients.
- Immune responses remained normal even when patients were in remission.
Conclusions:
- Leukemia patients in this study did not exhibit significant immune deficiencies.
- Cellular and humoral immunity appear to be preserved in leukemia, including during remission.
- Further research may explore the implications of preserved immunity in leukemia management.
Abstract:
In the present study delayed cutaneous hypersensitivity response (DNCB test) and humoral response (by uantification of immunoglobulins) ware carried out in 20 cases of leukaemias. None of the cases was found to be anergic or immunodeficient. In remission also patients showed the normal response.