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Updated: Aug 8, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 19, 2013
[Adult T-cell leukemia with Ki-1 expression]
1Department of Internal Medicine, Minami Kyushuu Chuo National Hospital.
Insights
This study identifies a link between Human T-lymphotropic virus type I (HTLV-I) activation and the expression of the Ki-1 antigen in adult T-cell leukemia (ATL) cells. Researchers observed increased Ki-1 antigen on ATL cells following HTLV-I exposure.
Area of Science:
- Hematology
- Oncology
- Virology
Background:
- Adult T-cell leukemia (ATL) is a lymphoproliferative disorder associated with Human T-lymphotropic virus type I (HTLV-I).
- The LSG classification categorizes lymphoma subtypes, including diffuse lymphoma pleomorphic type.
Observation:
- A 64-year-old male presented with fever and edema, diagnosed with diffuse lymphoma pleomorphic type.
- Hematological examination revealed abnormal lymphocytes expressing CD2, CD3, CD4, and CD25, with a positive anti-HTLV-I antibody test.
- ATL cells in blood and lymph nodes expressed CD30 (Ki-1), with increased CD30-positive ATL cells after short-term culture.
Findings:
- The study observed that ATL cells expressed CD30 (Ki-1).
- Short-term culture of ATL cells showed an increase in CD30-positive cells.
- Induction of Ki-1 antigen in cell lines and cultured ATL cells correlated with the appearance of HTLV-I related antigens.
Implications:
- Suggests a relationship between Ki-1 antigen expression and HTLV-I activation in ATL cells.
- Highlights the potential role of HTLV-I in modulating cell surface markers in ATL.
- Provides insights into the pathogenesis and potential therapeutic targets for ATL.
Abstract:
A 64-year-old man was admitted to our hospital complaining of fever and edema in February, 1990. Lymph node biopsy revealed diffuse lymphoma pleomorphic type according to the LSG classification. On hematological examination, leukocyte count was 23,500/microliters, of which 36% abnormal lymphocytes expressing CD2, CD3, CD4 and CD25 as same as the lymph node cells. Anti-HTLV-I antibody in serum was positive. From these data, the diagnosis of adult T-cell leukemia (ATL) was made. ATL cells in the blood and lymph node expressed CD30 (Ki-1). CD30 positive ATL cells derived from the blood was increased after short-term culture. The induction of Ki-1 antigen in cell lines and short-term cultured cells from ATL patients was accompanied by the appearance of the HTLV-I related antigen. Then, we suggest that there was some relation between expression of the Ki-1 antigen and activation by HTLV-I in ATL cells.
