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Ceroid granuloma of the uterine cervix
A I al Nafussi1, D Hughes, G Rebello
1Department of Pathology, University of Edinburgh, Scotland, UK.
Insights
This study reports the first known case of ceroid granuloma on the uterine cervix. Histology confirmed a rare pigment in macrophages within a cervical lesion.
Area of Science:
- Gynecologic Pathology
- Cervical Pathology
- Granulomatous Diseases
Background:
- Cervical lesions can present with diverse histopathological findings.
- Pigmented macrophages in subepithelial infiltrates are uncommon in cervical pathology.
- Ceroid deposition is a rare finding in granulomatous inflammation.
Observation:
- A 59-year-old woman presented with a small, dark-brown lesion on the anterior cervical lip.
- Excision biopsy revealed an ulcerated surface epithelium.
- Subepithelial tissue showed a band-like infiltrate of pigment-laden macrophages.
Findings:
- Histochemical analysis identified the pigment within macrophages as ceroid.
- The histological features are consistent with a ceroid granuloma.
- This represents the first documented case of ceroid granuloma of the uterine cervix.
Implications:
- This case expands the differential diagnosis for pigmented cervical lesions.
- Understanding ceroid deposition is crucial for accurate gynecologic pathology diagnosis.
- Further research may elucidate the etiology and clinical significance of cervical ceroid granuloma.
Abstract:
An excision biopsy was taken from a 59-year-old woman with a small dark-brown lesion on the anterior lip of the cervix. The histology revealed an ulcerated surface epithelium with a band-like infiltrate of pigment containing macrophages in the subepithelial zone. Histochemical examination of the specimen revealed that the pigment was ceroid. This is, to the best of our knowledge, the first case report of ceroid granuloma of the uterine cervix.