Related Experiment Video

Updated: Aug 8, 2026

Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation
08:08

Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation

Published on: July 8, 2011

NK cell and DC interactions

Megan A Cooper1, Todd A Fehniger, Anja Fuchs

  • 1The James Cancer Hospital and The Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA.

Trends in Immunology
|December 31, 2003
PubMed

Insights

Natural killer (NK) cells and dendritic cells (DCs) interact in the body, influencing immune responses. This study suggests these crucial interactions occur at inflammation sites and in lymph nodes.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Natural killer (NK) cells and dendritic cells (DCs) play vital roles in immune responses.
  • In vitro studies show NK-DC interactions influence immune cell activation, cytokine production, and DC maturation.

Purpose of the Study:

  • To investigate the in vivo locations where NK cells and DCs interact.
  • To determine if in vitro observed NK-DC crosstalk occurs within the human body.

Main Methods:

  • The study proposes potential in vivo interaction sites for human NK cells and DCs based on existing research and immunological principles.

Main Results:

  • Evidence suggests that NK cells and DCs interact in vivo at sites of inflammation.
  • Lymph nodes are also proposed as a key location for NK-DC interactions.

Conclusions:

  • NK-DC interactions are crucial for immune responses.
  • These interactions likely occur in vivo at inflammation sites and within lymph nodes, providing new insights into immune cell communication.

More Related Videos

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Functionalization of Atomic Force Microscope Cantilevers with Single-T Cells or Single-Particle for Immunological Single-Cell Force Spectroscopy10:06

Functionalization of Atomic Force Microscope Cantilevers with Single-T Cells or Single-Particle for Immunological Single-Cell Force Spectroscopy

Published on: July 10, 2019

Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...