Related Experiment Video

Updated: Aug 2, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

CLA(+) T cells in cutaneous diseases

Luis F Santamaria-Babí1

  • 1Almirall Prodesfarma, Research Center, Cardener, 68-74, 08024 Barcelona, Spain. Lsantama@almirallprodesfarma.com

European Journal of Dermatology : EJD
|February 18, 2004
PubMed

Insights

The Cutaneous Lymphocyte-associated Antigen (CLA) identifies skin-homing T cells involved in skin disease. Targeting these CLA(+) T cells offers a novel approach for treating T cell-mediated dermatological conditions.

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • The Cutaneous Lymphocyte-associated Antigen (CLA) was initially identified on T lymphocytes in the skin.
  • Emerging research reveals CLA's role beyond a simple surface marker.

Purpose of the Study:

  • To elucidate the function of CLA(+) T cells in cutaneous diseases.
  • To explore CLA(+) T cells as therapeutic targets in dermatology.

Main Methods:

  • Immunohistochemistry and flow cytometry to identify and characterize CLA(+) T cells.
  • Functional assays to assess the role of CLA(+) T cells in skin inflammation models.

Main Results:

  • CLA(+) T cells represent a subset of memory effector T lymphocytes.
  • These cells are functionally implicated in the pathogenesis of various T cell-mediated skin disorders.

Conclusions:

  • CLA(+) T cells are key players in the mechanisms underlying skin diseases.
  • Targeting CLA(+) T cells presents a promising strategy for developing new dermatological treatments.

More Related Videos

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...