Related Experiment Video

Updated: Aug 8, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C]

Maja Jovanović1, Ljiljana Konstantinović, Vuka Katić

  • 1Klinicki centar-Nis, Klinika za zarazne bolesti, Nis. pedjaj@bankerinter.net

Vojnosanitetski Pregled
|March 17, 2004
PubMed

Insights

Lymphocyte and macrophage infiltration in the liver directly correlates with liver damage severity in chronic hepatitis C virus (HCV) infection. This finding aids in understanding HCV pathogenesis.

Area of Science:

  • Hepatology
  • Immunology
  • Virology

Context:

  • Chronic hepatitis C virus (HCV) infection involves immunologically mediated liver damage.
  • Liver parenchyma infiltration by lymphocytes is a key feature.

Purpose:

  • To perform histological, histochemical, and immunocytochemical assessments of liver biopsy specimens.
  • To analyze liver biopsy samples from patients with chronic HCV infection.

Summary:

  • Twenty chronic HCV patients' liver biopsies were analyzed using standard and immunoenzymatic staining.
  • Micromorphologic analysis revealed mononuclear lympho-plasmocytic infiltration and macrophages, particularly in the portal space.
  • Immunocytochemistry confirmed a correlation between cellular infiltration and disease activity.

Impact:

  • Lymphocytic and macrophageal infiltration intensity correlates with liver damage severity.
  • Analyzing cellular infiltrate populations can help elucidate the pathogenesis of chronic hepatitis C.
  • Combined with viremia and necrosis monitoring, cellular infiltrate analysis offers insights into disease mechanisms.
Abstract

More Related Videos

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Mapping Hepatic Stellate Cell Morphology in Mouse Models of Liver Fibrosis06:55

Mapping Hepatic Stellate Cell Morphology in Mouse Models of Liver Fibrosis

Published on: February 13, 2026

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...