Related Experiment Video

Updated: Aug 9, 2026

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy
10:22

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Published on: November 29, 2017

Divide and conquer: the importance of cell division in regulating B-cell responses

Stuart G Tangye1, Philip D Hodgkin

  • 1Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2042, NSW, Australia. s.tangye@centenary.usyd.edu.au

Immunology
|July 24, 2004
PubMed

Insights

Cell division is crucial for immune responses, influencing antibody production and memory cell development. New research highlights its role in regulating antibody isotype class and protective immunity in B cells.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Clonal selection requires cell proliferation for expanding antigen-reactive clones.
  • This expansion is vital for developing antibody diversity and memory cells.

Purpose of the Study:

  • To investigate the role of cell division in B cell development.
  • To understand how division regulates antibody isotype class.
  • To determine division's impact on protective immunity.

Main Methods:

  • Analysis of mouse and human B cell data.
  • Investigating cell division dynamics.

Main Results:

  • Cell division plays a significant role in regulating antibody isotype class.
  • Regulated entry into the plasma cell lineage is influenced by cell division.
  • Division optimizes the development of protective immunity.

Conclusions:

  • Cell division is a key regulator of B cell differentiation and function.
  • Understanding B cell division is critical for developing effective vaccines and immunotherapies.

More Related Videos

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Analysis of Multidimensional Microscopy Data Using Cell-ACDC06:17

Analysis of Multidimensional Microscopy Data Using Cell-ACDC

Published on: November 7, 2025

Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...