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Published on: January 12, 2024
B-cell conjunctival lymphoma in a cat
Zaher A Radi1, Debra L Miller, Murray E Hines
1Veterinary Diagnostic & Investigational Laboratory, College of Veterinary Medicine, The University of Georgia, 43 Brighton Road, Tifton, GA 31793-1389, USA. zradi@tifton.uga.edu
Insights
This study details the first immunohistochemical characterization of conjunctival lymphoma in a cat. A bilateral conjunctival neoplasm was diagnosed as B-cell lymphoma in a feline patient.
Area of Science:
- Veterinary Pathology
- Ophthalmology
- Oncology
Background:
- Conjunctival neoplasms in felines can present diagnostic challenges.
- Accurate diagnosis is crucial for appropriate treatment and prognosis.
Observation:
- A 13-year-old Domestic Short-haired cat presented with a bilateral conjunctival neoplasm.
- Surgical excision and histopathological examination were performed.
Findings:
- The neoplasm was infiltrative and composed of densely packed, round to polygonal cells.
- Immunohistochemistry revealed positive staining for BLA.36 and negative staining for CD-3.
- A diagnosis of conjunctival B-cell lymphoma was established.
Implications:
- This case represents the first immunohistochemical characterization of feline conjunctival lymphoma.
- Findings contribute to the understanding of feline ocular oncology.
- Establishes a precedent for diagnostic methodology in similar cases.
Abstract:
A bilateral conjunctival neoplasm was surgically removed from a 13-year-old Domestic Short-haired female cat and examined by histopathology. The neoplasm was infiltrative, nonencapsulated and composed of large sheets of densely packed, round to polygonal cells. Neoplastic cells were variably sized with scant to modest amounts of cytoplasm and oval to round nuclei. On immunohistochemistry the neoplastic cells stained positively for BLA.36 and negative for CD-3 antibodies. On the basis of histopathology and immunohistochemical findings, a diagnosis of conjunctival B-cell lymphoma was made. This is the first case with immunohistochemical characterization of conjunctival lymphoma in a cat.
