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Coexpression of CD43 by benign B cells in the terminal ileum

Po-Shing Lee1, Debra Beneck, James Weisberger

  • 1From Division of Hematopathology, IMPATH Inc, New York, NY 10019, USA.

Applied Immunohistochemistry & Molecular Morphology : AIMM
|May 17, 2005
PubMed

Insights

CD43 expression on B cells can indicate lymphoproliferative disorders. However, benign B cells in the terminal ileum frequently express CD43, making it unreliable for diagnosing MALT lymphoma versus reactive conditions.

Area of Science:

  • Immunohistochemistry
  • B-cell lymphomas
  • Gastrointestinal pathology

Background:

  • CD43 expression on B cells is a diagnostic marker for B-cell lymphoproliferative disorders.
  • Benign B cells typically do not coexpress CD43.
  • Distinguishing extranodal marginal zone B-cell lymphoma of MALT type from reactive processes can be challenging.

Purpose of the Study:

  • To investigate CD43 expression in benign B cells within the terminal ileum.
  • To determine if CD43 coexpression in the terminal ileum is a reliable indicator of B-cell lymphoproliferative disorders.

Main Methods:

  • Analysis of 20 terminal ileum biopsies for nonneoplastic disease.
  • Assessment of CD43 expression alongside CD20, CD138, and CD3 reactivity.
  • Comparison of CD43 expression in the terminal ileum with other anatomical sites.

Main Results:

  • 85% of cases showed strong CD43 coexpression in benign perifollicular B cells.
  • Benign B cells in the terminal ileum, including Peyer's patches, frequently express CD43.
  • CD43 coexpression was observed in benign B-cell populations.

Conclusions:

  • CD43 coexpression in terminal ileum B cells, including Peyer's patches, is common in benign conditions.
  • CD43 should not be used as a sole diagnostic marker to differentiate MALT lymphoma from reactive processes in the terminal ileum.

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