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Cytomegalovirus cholangitis and pancreatitis in an immunocompetent patient

Takatomi Oku1, Masahiro Maeda, Eriko Waga

  • 1Department of Gastroenterology, Shinnittetsu Muroran General Hospital, 1-45 Chiribetsu-cho, Muroran, 050-0076, and Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.

Journal of Gastroenterology
|November 2, 2005
PubMed

Insights

Cytomegalovirus (CMV) infection caused cholangitis and pancreatitis in an immunocompetent patient, a rare occurrence. This case highlights CMV as a potential cause of bile duct stenosis and pancreatitis, even in individuals with normal immune function.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Infectious Diseases

Background:

  • Cytomegalovirus (CMV) infections typically affect immunocompromised individuals.
  • CMV-associated cholangitis and pancreatitis are uncommon complications, particularly in immunocompetent hosts.

Observation:

  • A 55-year-old immunocompetent male presented with jaundice and liver dysfunction.
  • Endoscopic retrograde cholangiography revealed distal common bile duct stenosis.
  • Histopathology of the resected specimen confirmed chronic cholangitis and CMV pancreatitis.

Findings:

  • Immunohistochemistry confirmed CMV infection in the inflamed bile duct epithelium.
  • The findings were consistent with CMV cholangitis and CMV pancreatitis.

Implications:

  • This case suggests CMV cholangitis and pancreatitis should be considered in the differential diagnosis of common bile duct stenosis and pancreatitis.
  • Even in immunocompetent individuals, CMV should be considered in unexplained biliary or pancreatic inflammation.

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