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[Cerebral lymphomatoid granulomatosis. A case report]
C Seifried1, S Weidauer, N Hinsch
1Klinik für Neurologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main. C.Seifried@em.uni-frankfurt.de
Insights
This case study details a 57-year-old patient diagnosed with lymphomatoid granulomatosis. Despite treatment with rituximab and cyclophosphamide, the patient succumbed to the rare disease within three months.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Lymphomatoid granulomatosis is a rare lymphoproliferative disorder.
- Early diagnosis and treatment are crucial for managing this condition.
Observation:
- A 57-year-old patient presented with fever and disorientation.
- Cerebrospinal fluid analysis revealed mild pleocytosis and elevated protein.
- MR imaging demonstrated multiple subcortical white matter lesions with characteristic enhancement.
Findings:
- Open lung biopsy confirmed the diagnosis of lymphomatoid granulomatosis.
- The patient received rituximab and cyclophosphamide for treatment.
Implications:
- This case highlights the diagnostic challenges of lymphomatoid granulomatosis.
- Aggressive treatment regimens may be necessary.
- The disease carries a poor prognosis, emphasizing the need for further research.
Abstract:
We present the case of a 57-year-old patient who was admitted with fever and disorientation. The cerebrospinal fluid showed a mild pleocytosis and increased protein content. MR imaging revealed multiple lesions, particularly in the subcortical white matter, with spot like central contrast enhancement. The diagnosis of lymphomatoid granulomatosis was finally made through open lung biopsy. Despite treatment with rituximab and, in the later course of the disease, additionally with cyclophosphamide, the patient died 3 months after the diagnosis was made.
