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Association between cytomegalovirus infection and venous thromboembolism

Zvi G Fridlender1, Mogher Khamaisi, Eran Leitersdorf

  • 1Division of Medicine, Hadassah--Hebrew University Medical Center, Jerusalem, Israel. fridlender@hadassah.org.il

The American Journal of the Medical Sciences
|August 19, 2007
PubMed

Insights

Cytomegalovirus (CMV) infection may increase the risk of blood clots (thrombosis) in both immunocompromised and immunocompetent individuals. Clinicians should consider CMV infection as a potential risk factor for thrombophilia.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Clinical Medicine

Background:

  • Cytomegalovirus (CMV) infection is a known concern in immunocompromised patients.
  • Sporadic reports suggest a link between CMV and thrombotic events in immunocompetent individuals.

Observation:

  • This study reports on nine adult patients (1 immunocompromised, 8 immunocompetent) who experienced venous thromboembolic events during acute CMV infection.
  • None of the patients had a prior history of thromboembolic events.

Findings:

  • Seven patients presented with vein thromboses.
  • Five patients had identifiable thrombophilia, including elevated anti-cardiolipin IgM antibodies in one case.

Implications:

  • CMV infection should be recognized as a potential risk factor for thrombophilia.
  • A high index of suspicion for thrombotic events is warranted in patients with CMV infection.
  • Consideration of prophylactic anticoagulation may be necessary.

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