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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Published on: August 9, 2024

[Primary cutaneous plasmacytoma]

Rym Dhouib Sellami1, Samia Sassi, Karima Mrad

  • 1Service d'Anatomie et de Cytologie Pathologiques, Hôpital régional de Zaghouan, Tunis, Tunisie.

Annales De Pathologie
|October 3, 2007
PubMed

Insights

Primary cutaneous plasmacytoma (PCP), a rare B cell lymphoma, presents as a cheek nodule. Solitary lesions show a good prognosis and are treated with surgery and radiotherapy.

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous plasmacytoma (PCP) is an uncommon B cell lymphoma affecting the skin.
  • It is crucial to differentiate PCP from metastatic myeloma lesions due to prognostic differences.

Observation:

  • A case of PCP in a 64-year-old woman with a nodular lesion on the left cheek is presented.
  • Histological examination revealed predominantly mature plasma cells with monotypic lambda chain expression.
  • Extracutaneous involvement was ruled out.

Findings:

  • The lesion was characterized by variably matured plasma cells with a single type of light chain (monotypic lambda).
  • No evidence of disease spread to other organs was found.

Implications:

  • PCP generally has a better prognosis than metastatic myeloma skin lesions.
  • Tumor size and clinical presentation (solitary vs. multiple lesions) are key prognostic factors.
  • Solitary PCP lesions are effectively managed with surgical excision, potentially combined with radiotherapy.

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