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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Published on: May 18, 2018

CD83 regulates lymphocyte maturation, activation and homeostasis

Minka Breloer1, Bernhard Fleischer

  • 1Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany. breloer@bni-hamburg.de

Trends in Immunology
|March 11, 2008
PubMed

Insights

CD83, a cell surface marker on dendritic cells (DCs), regulates T- and B-lymphocyte maturation and peripheral responses. This review explores CD83

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD83 is a transmembrane molecule and immunoglobulin superfamily member.
  • It is a key cell surface marker for mature dendritic cells (DCs) in circulation.

Purpose of the Study:

  • Review evidence for CD83's role in central lymphocyte maturation.
  • Discuss novel and contradictory findings on CD83's function in peripheral immune responses.

Main Methods:

  • Literature review of existing studies on CD83.
  • Analysis of data regarding CD83's function in immune cell development and response.

Main Results:

  • CD83's essential role on murine DCs is not established.
  • Evidence suggests CD83 primarily regulates T- and B-lymphocyte maturation and peripheral responses.

Conclusions:

  • CD83 plays a regulatory role in lymphocyte maturation.
  • Further research is needed to clarify CD83's complex functions in immune responses.

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