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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
A clinicopathologic study of mantle cell lymphoma in a single center study in India
1Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India. s_gujral@hotmail.com
Insights
Mantle cell lymphoma (MCL) is a rare non-Hodgkin's lymphoma (NHL). Advanced-stage disease and diffuse nodal patterns are associated with poorer outcomes in MCL patients.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is an uncommon subtype of non-Hodgkin's lymphoma (NHL).
- Understanding the clinical and pathological characteristics of MCL is crucial for effective management.
Purpose of the Study:
- To analyze the clinical features, histopathology, and treatment outcomes of MCL cases.
- To identify prognostic factors influencing survival in MCL.
Main Methods:
- Retrospective review of 93 MCL cases over a 4-year period.
- Analysis of histopathology, immunohistochemistry (CD20, CD43, CD5, cyclin D1), staging, and treatment data.
- Evaluation of recurrence-free survival and overall survival.
Main Results:
- MCL constituted 2.1% of NHL cases; 68 were histopathologically confirmed.
- Most patients (85%) presented with advanced-stage disease, predominantly nodal (63 cases).
- Common immunophenotypes included CD20+, CD43+, CD5+, and cyclin D1+; diffuse nodal pattern correlated with lower survival.
Conclusions:
- MCL is typically diagnosed at an advanced stage with specific immunophenotypic markers.
- The diffuse pattern of nodal involvement is a negative prognostic indicator for overall survival in MCL.
Abstract:
We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.
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