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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation

Maurice J Schuetz1, Nadeem Zafar, Mohammad A Vasef

  • 1Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Southern Medical Journal
|March 13, 2009
PubMed

Insights

Mantle cell lymphoma (MCL) is a B-cell cancer characterized by CD5 antigen coexpression. While cyclin D1 positivity is diagnostic, MCL can mimic other lymphomas morphologically.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Mantle cell lymphoma (MCL) is a mature B-cell neoplasm defined by CD5 antigen coexpression.
  • Genetic hallmark t(11;14) leads to cyclin D1 protein upregulation in MCL.
  • Diagnosis typically relies on morphology, CD20/CD5 coexpression, and cyclin D1 immunohistochemistry.

Purpose of the Study:

  • To investigate unusual morphologic presentations of mantle cell lymphoma.
  • To highlight diagnostic challenges posed by MCL mimicking other B-cell lymphomas.

Main Methods:

  • Immunohistochemical confirmation of cyclin D1 positivity in MCL cases.
  • Morphologic analysis of MCL with overlapping features of other B-cell lymphomas.

Main Results:

  • Identified cases of cyclin D1-positive MCL exhibiting diverse morphologic features.
  • Observed overlap with follicular, marginal zone, small lymphocytic, and Burkitt lymphomas.

Conclusions:

  • Mantle cell lymphoma can present with significant morphologic heterogeneity.
  • Awareness of these overlapping features is crucial for accurate diagnosis and patient management.

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