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Excretion of technetium 99m hexakismethoxyisobutylisonitrile in milk

S M Rubow1, A Ellmann, J le Roux

  • 1Department of Nuclear Medicine, Tygerberg Hospital, Republic of South Africa.

European Journal of Nuclear Medicine
|January 1, 1991
PubMed

Insights

Technetium 99m hexamethoxyisobutylisonitrile (99mTc-MIBI) myocardial scintigraphy shows minimal radioactivity in breast milk. This suggests breastfeeding can continue after 99mTc-MIBI administration without interruption.

Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Cardiology

Background:

  • Myocardial scintigraphy is crucial for diagnosing cardiac conditions.
  • Technetium 99m hexamethoxyisobutylisonitrile (99mTc-MIBI) is a common radiopharmaceutical used in these scans.
  • Assessing the excretion of 99mTc-MIBI into breast milk is important for nursing mothers undergoing this procedure.

Observation:

  • Radioactivity levels in breast milk were measured after 99mTc-MIBI administration.
  • The study quantified the total amount and concentration of 99mTc excreted in milk over 24 hours.
  • High concentrations of 99mTc-MIBI were observed in the lactating breast tissue itself.

Findings:

  • Only a very small fraction (0.0084%) of the injected 99mTc dose was excreted in breast milk within 24 hours.
  • The total radioactivity excreted was 41.2 kBq in 448 ml of milk.
  • The highest concentration of 99mTc in milk was 0.49 kBq/ml in the first sample collected.

Implications:

  • The minimal excretion of 99mTc-MIBI in breast milk suggests low risk to the infant.
  • Current recommendations for radiopharmaceutical administration and breastfeeding may not require interruption for 99mTc-MIBI.
  • This study supports the continuation of breastfeeding for mothers undergoing 99mTc-MIBI myocardial scintigraphy.

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