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Thymic seminoma
J Kannan1, P Karkuzhali, S Lakshminarasimhan
1Department of Medical Oncology, Institute of Pathology, Madras Medical College, Chennai, India.
Insights
A rare thymic seminoma case in an 18-year-old male recurred after surgery with widespread metastases. Treatment involved chemotherapy with cisplatin, bleomycin, and etoposide.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Thymic seminoma is an uncommon germ cell tumor.
- Early diagnosis and treatment are crucial for prognosis.
Observation:
- An 18-year-old male presented with symptoms of an anterior mediastinal mass.
- Imaging revealed a mass, later pathologically confirmed as thymic seminoma.
Findings:
- The patient experienced local recurrence and distant metastases (lung, lymph nodes) after initial surgical resection.
- Recurrence occurred despite an asymptomatic period post-surgery.
Implications:
- This case highlights the aggressive nature of thymic seminoma and the need for vigilant follow-up.
- Multimodal treatment, including chemotherapy, is essential for managing advanced or recurrent thymic seminoma.
Abstract:
Thymic seminoma is a rare clinical entity. We report a case of an 18-year-old male patient who presented with chest pain, dyspnea, dysphagia of 1-month duration. Contrast-enhanced computer tomogram of chest showed an anterior mediastinal mass. He was subjected to thoracotomy and excision of the mass. Histopathology examination revealed seminoma of thymus. He failed to follow up for a period of 8 months post-surgery as he was asymptomatic. He then presented with a recurrence of the tumor locally, along with metastases to the lung, para-aortic and peri-aortic lymph nodes. He was kept on cisplatin, bleomycin and etoposide.
