Related Experiment Video
Updated: Jun 8, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[Pathology of malignant lymphomas--clarity instead of confusion]
Esther Mueller-Garamvölgyi1, Aurel Perren, Anja Schmitt
1Institut für Pathologie, Universität Bern, Bern. esther.mueller@pathology.unibe.ch
Insights
The WHO classification provides clear lymphoma diagnosis, aiding in identifying mature B-cell and Hodgkin lymphomas. Modern diagnostics integrate morphology, immunohistochemistry, and molecular studies for accurate lymphoma classification.
Area of Science:
- Hematology
- Oncology
- Pathology
Context:
- Lymphoma classification has evolved significantly, moving from decades of confusion to clarity with the Revised European-American Lymphoma (REAL) classification in 1994 and the World Health Organization (WHO) classification in 2001.
- The 2008 WHO classification (4th edition) further refined categories, encompassing B- and T-lymphoblastic neoplasms, mature B-cell lymphomas, mature T-cell and NK-cell lymphomas, and Hodgkin lymphomas.
Purpose:
- To provide an overview of the most frequent mature B-cell lymphomas.
- To highlight the most important classical Hodgkin lymphomas.
- To focus on the morphological and immunohistochemical features crucial for diagnosis.
Summary:
- Modern lymphoma diagnosis relies on a multi-faceted approach, integrating morphology, immunohistochemistry, and molecular studies.
- Expert hematopathologist evaluation, in close collaboration with clinicians, is essential for interpreting diagnostic findings.
- The WHO classification serves as the current standard for categorizing various lymphoma subtypes.
Impact:
- Improved diagnostic clarity for lymphomas, facilitating more precise patient management.
- Enhanced understanding of mature B-cell and classical Hodgkin lymphomas through a focus on key diagnostic markers.
- Establishes a foundation for consistent and accurate lymphoma diagnosis and subtyping in clinical practice.
Abstract:
After decades of confusion in lymphoma classification clearness was achieved with the publication of the REAL classification 1994 and of the WHO classification 2001. The revised 4th edition 2008 features some additional new categories. The WHO classification comprises B- and T-lymphoblastic neoplasms, mature B-cell lymphomas, mature T-cell and NK-cell lymphomas and Hodgkin lymphomas. A modern diagnostic work-up of lymphomas is based on morphology, immunohistochemistry and increasingly on molecular studies. Last but not least the evaluation of all these findings by an expert haematopathologist, who collaborates closely with the treating clinicians, is essential. The aim is to give an overview of the most frequent mature B-cell lymphomas and the most important classical Hodgkin lymphomas with focus on morphology and immunohistochemistry.
Related Concept Videos
01:23Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
01:18Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:16Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...