Related Experiment Video

Updated: Jun 6, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

The importance of pursuing a histological diagnosis in the HIV setting

K A Fernando1, S Acharya, J T Arumaninayagam

  • 1Walsall Centre for Sexual Health, Walsall Hospitals NHS Trust, Pleck Road, Walsall WS2 7BR, UK. kafernando@hotmail.com.

The Journal of the Royal College of Physicians of Edinburgh
|December 15, 2010
PubMed

Insights

Persistent symptoms despite initial treatment in an HIV-positive man led to a correct diagnosis of Hodgkin's disease. This case highlights the importance of histological confirmation for accurate diagnosis and effective patient management.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Pathology

Background:

  • A 40-year-old African man presented with constitutional symptoms and lymphadenopathy.
  • Human immunodeficiency virus (HIV) infection was confirmed.
  • Initial presentation mimicked other conditions, leading to empirical treatment.

Purpose of the Study:

  • To report a case of Hodgkin's disease in an HIV-positive individual.
  • To emphasize the diagnostic challenges in immunocompromised patients.
  • To highlight the importance of persistent diagnostic investigation.

Main Methods:

  • Clinical presentation review.
  • Diagnostic lymph node biopsy.
  • Histopathological examination.
  • Empirical treatment for tuberculosis.

Main Results:

  • Initial lymph node biopsy showed reactive hyperplasia.
  • Empirical tuberculosis treatment was ineffective.
  • Repeat biopsy confirmed Hodgkin's disease.

Conclusions:

  • Hodgkin's disease can present insidiously in HIV-positive individuals.
  • Persistent symptoms warrant further diagnostic investigation beyond initial findings.
  • Histological diagnosis is crucial for managing complex cases, especially in immunocompromised patients.

More Related Videos

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...