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Intranuclear inclusions in epithelial cells of benign proliferative breast lesions

Oi Harada1, Rebecca Hoe, Jieyan Lin

  • 1Department of Pathology, Singapore General Hospital, Singapore.

Journal of Clinical Pathology
|May 25, 2011
PubMed

Insights

Intranuclear inclusions in benign breast lesions appear to originate from the cytoplasm. Further research is needed to fully understand the formation of these helioid bodies.

Area of Science:

  • Breast pathology
  • Cell biology
  • Histopathology

Background:

  • Intranuclear inclusions in breast epithelium are observed in benign proliferative lesions.
  • Their precise nature and origin require detailed investigation.

Purpose of the Study:

  • To document and clarify the nature of intranuclear inclusions within the luminal epithelium of benign breast lesions.
  • To investigate the origin and morphology of these inclusions.

Main Methods:

  • Selection of five benign breast lesions exhibiting intranuclear inclusions.
  • Confirmation of luminal epithelial localization via immunohistochemistry.
  • Ultrastructural examination for detailed morphological analysis.

Main Results:

  • Observed deep nuclear indentations resembling inclusions.
  • Identified inclusions with characteristics of helioid bodies.
  • Documented a morphological spectrum and focal coexistence of helioid bodies.

Conclusions:

  • Intranuclear inclusions in breast epithelium are likely of cytoplasmic origin.
  • Helioid bodies may form through a stepwise process requiring further elucidation.
Abstract

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