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Pendrin: the thyrocyte apical membrane iodide transporter?

Laure Twyffels1, Claude Massart, Philippe E Golstein

  • 1Molecular Biology of the Gene Laboratory and Center of Microscopy and Molecular Imaging, University of Brussels, IBMM, Campus Gosselies, Brussels, Belgium.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|November 26, 2011
PubMed

Insights

Pendrin

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Biology

Background:

  • Thyroid iodide uptake involves basal and apical transport.
  • The Na(+)/I(-) symporter (NIS) mediates basal uptake.
  • Pendrin is traditionally assumed to mediate apical iodide efflux.

Purpose of the Study:

  • To critically evaluate the role of pendrin in thyroid iodide transport.
  • To investigate alternative functions of pendrin in thyroid physiology.

Main Methods:

  • Review of biochemical, clinical, and histological data.
  • Analysis of pendrin knockout mouse models.
  • In vivo and in vitro experiments on polarized and unpolarized cells.
  • Ectopic expression of pendrin in non-thyroid cells.

Main Results:

  • Pendred syndrome patient data and pendrin knockout mice do not support an essential role for pendrin in iodide transport.
  • Experiments demonstrate pendrin's capacity for iodide efflux.
  • Pendrin may contribute to apical iodide transport but is not the sole transporter.

Conclusions:

  • Pendrin's role in thyroid iodide transport is not unique.
  • Pendrin may be involved in Cl(-)/HCO(3)(-) exchange.
  • Pendrin might play a role in controlling luminal pH in the thyroid.

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