Related Experiment Video
Updated: Aug 13, 2026
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[Serum paraprotein in a patient with chronic lymphatic leukemia]
G D'Angelo1, M D Zanco, C Giardini
1Laboratorio Analisi Chimico-Cliniche e Microbiologiche, U.S.S.L. n. 6, Gallarate, Varese.
Insights
This study details a rare case of chronic lymphocytic leukemia with a specific paraproteinemia, IgM lambda. It highlights how cellular changes in leukemia can lead to highly active plasma cells.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy.
- Paraproteinemia, the presence of abnormal proteins in the blood, can occur in CLL.
- Immunoglobulin M (IgM) lambda paraproteinemia is a less common finding in CLL.
Abstract:
We report a case of chronic lymphocytic leukemia associated with paraproteinemia which proved to be a complete immunoglobulin IgM lambda. This case is reported because the process of cellular differentiation exposed to intrinsic or extrinsic stimulation may undergo morphofunctional variations which lead to the formation of plasma cells with extremely high secretionary capacities during the course of chronic lymphocytic leukemia.
