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[Primary malignant lymphoma of the urinary bladder: report of a case]
K Murayama1, T Katsumi, K Watanabe
1Department of Urology, Kanazawa National Hospital.
Insights
This case study presents a rare primary malignant lymphoma of the bladder in a 42-year-old woman. Surgical resection and chemotherapy led to a favorable outcome with no recurrence after 16 months.
Area of Science:
- Urology
- Oncology
- Hematology
Background:
- Primary malignant lymphoma of the bladder is a rare non-epithelial tumor.
- Early diagnosis is crucial for effective treatment and patient outcomes.
Observation:
- A 42-year-old woman presented with asymptomatic hematuria.
- Diagnostic imaging (cystoscopy, IVP, ultrasonography, CT scan) suggested a bladder tumor.
- Transurethral biopsy confirmed non-Hodgkin lymphoma.
Findings:
- Systemic staging (CT, Ga-scintigraphy, bone marrow biopsy) showed no extranodal involvement, confirming primary bladder lymphoma.
- Histopathology revealed follicular lymphoma, medium-sized cell type (B-cell).
- Tumor size was 2 x 1 cm, invading the muscularis layer.
Implications:
- Partial cystectomy with pelvic lymph node resection followed by adjuvant chemotherapy (vincristine, cyclophosphamide, prednisolone) was successful.
- The patient remained disease-free for 16 months post-operation.
- This case highlights the importance of considering lymphoma in bladder tumor differential diagnoses and successful multimodal treatment approaches.
Abstract:
A case of primary malignant lymphoma of the bladder is presented. A 42-year-old woman was admitted to our clinic with the chief complaint of asymptomatic hematuria. Examination of cystoscopy, IVP, ultrasonography and CT scan suggested a non-epithelial tumor of the bladder, which was reported as malignant lymphoma, non-Hodgkin, by findings of transurethral biopsy. Subsequent systemic CT scan, Ga-scintigraphy and bone marrow puncture revealed no abnormalities. Therefore, this case was thought to be primary malignant lymphoma of the bladder. Partial cystectomy with pelvic lymph node resection was carried out. The tumor, 2 x 1 cm in diameter, invaded into the middle portion of muscularis. Histological diagnosis of the tumor was follicular lymphoma, medium-sized cell type according to LSG classification, and immunohistological findings also showed B-cell lymphoma. Resected lymph nodes had no signs of neoplasms. Postoperative adjuvant chemotherapy consisting of vincristine, cyclophosphamide and prednisolone was performed. She has been doing well without any clinical evidence of recurrence for 16 months after the operation.