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Published on: September 16, 2018
[Indolent CD8+ lymphoid proliferation on the nose]
1Service de dermatologie, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
Insights
A rare skin condition, indolent CD8+ lymphoid proliferation, can affect the ear and nasal crest. Despite concerning histology, these lesions typically show slow progression and may respond to topical corticosteroids.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Reports a rare cutaneous T-cell lymphoma variant: indolent non-epidermotropic CD8+ lymphoid proliferation of the ear.
- This entity is distinct from previously described cutaneous T-cell lymphomas.
Observation:
- Presents a case of indolent CD8+ lymphoid proliferation involving the nasal crest in an 87-year-old woman.
- The lesion was a pigmented papule present for 9 years with spontaneous regression.
- Histopathology revealed dense dermal lymphoid infiltration with a monomorphous CD8+ lymphocyte population.
Findings:
- The condition is characterized by non-symptomatic infiltrated lesions, often on the ear, potentially bilateral.
- Histological findings can appear concerning due to dense cellular infiltrate.
- Despite worrying histology, the condition typically exhibits indolent progression.
Implications:
- Highlights the importance of recognizing indolent CD8+ lymphoid proliferation as a distinct entity.
- Suggests topical corticosteroids as a potential treatment option.
- Contributes to the understanding of rare lymphoid proliferations in the skin.
Background:
Indolent non-epidermotropic CD8+ lymphoid proliferation of the ear was recently reported in the literature by Petrella et al. This is a distinct entity related to cutaneous T-cell lymphomas. Herein, we report a case of indolent CD8+ lymphoid proliferation of the ear involving the nasal crest and we relate a number of cases recently published in the literature.
Patients And Methods:
An 87-year-old woman consulted for a pigmented papular lesion of the nasal crest present for 9 years that had begun to regress spontaneously. The remainder of the examination revealed nothing of note. The biopsy showed dense lymphoid infiltration within the dermis. Immunohistochemical analysis supported the diagnosis of indolent CD8+ lymphoid proliferation. Treatment with moderate topical corticosteroids was initiated.
Discussion:
This novel entity is characterised by the presence of relatively non-symptomatic infiltrated lesions in the ear, which can occur bilaterally. Histological findings are frequently worrying with the presence of a dense cellular infiltrate comprising a relatively monomorphous population of CD8+ lymphocytes, although progression is usually indolent.
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