Related Experiment Video

Updated: May 14, 2026

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Cytomegalovirus infection among Iranian kidney graft recipients

Z R Khameneh1, N Sepehrvand, T Aghazadeh

  • 1Urmia University of Medical Sciences, Urmia, Iran.

Transplantation Proceedings
|February 5, 2013
PubMed

Insights

Cytomegalovirus (CMV) infection is common after kidney transplants. This study found a high CMV infection rate in Urmia, Iran, using PCR detection in renal transplant recipients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Cytomegalovirus (CMV) infection is a significant complication in kidney transplant recipients.
  • Understanding CMV prevalence is crucial for post-transplant management.

Purpose of the Study:

  • To determine the seroprevalence and incidence of CMV infection in renal transplant recipients in Urmia, Iran.
  • To utilize polymerase chain reaction (PCR) for accurate CMV detection.

Main Methods:

  • A cross-sectional study involving 96 renal transplant recipients.
  • Blood samples were analyzed for anti-CMV IgM antibodies.
  • PCR assays were performed on seropositive and selected seronegative cases to confirm CMV infection.

Main Results:

  • 37.5% of recipients were seropositive for anti-CMV IgM (including borderline cases).
  • CMV infection was confirmed by PCR in 52.7% of seropositive individuals.
  • No significant association was found between CMV infection and patient demographics or pre-transplant factors.

Conclusions:

  • The study confirms a high seroprevalence of CMV infection among renal transplant recipients in Urmia, Iran.
  • PCR is an effective method for diagnosing CMV infection in this population.
Abstract

More Related Videos

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...