Related Experiment Video
Updated: Apr 12, 2026
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
CD 30-positive transformed follicular lymphoma: two case reports and literature review
Santiago Montes-Moreno1, Fina Climent2, Sonia González de Villambrosía1
1Pathology and Hematology Departments, Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
Insights
Follicular lymphoma can transform into CD30-positive diffuse large B cell lymphoma. CD30 expression indicates this transformation and suggests it as a therapeutic target for follicular lymphoma treatment.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Follicular lymphoma is a common indolent non-Hodgkin lymphoma.
- Transformation to a more aggressive lymphoma subtype can occur.
- CD30 expression is a marker often associated with lymphoma progression.
Observation:
- Two cases of follicular lymphoma transforming into CD30-positive diffuse large B cell lymphoma are presented.
- Genetic and molecular analyses confirmed the clonal relationship between the initial and transformed lymphoma components.
- One patient achieved complete response with high-dose therapy and auto-stem cell transplant (SCT).
- The second patient showed partial response to rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
Findings:
- CD30 expression was identified in both cases during the transformation event.
- The findings support CD30 as a marker for follicular lymphoma transformation.
- Immunoglobulin (Ig)H and cytogenetic identity confirmed transformation in the first case.
- Immunoglobulin K deleting element (IgKde) and cytogenetic identity confirmed transformation in the second case.
Implications:
- CD30 expression may serve as a crucial therapeutic target in transformed follicular lymphoma.
- Targeting CD30 could enhance conventional immunochemotherapy regimens.
- Combination therapy including auto-SCT with CD30-targeted agents may be beneficial.
- Routine assessment for CD30 expression in transformed follicular lymphoma is recommended.
Aims:
Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic.
Results:
The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immunoglobulin (Ig)H and cytogenetic identity was demonstrated between both components. High-dose and auto-stem cell transplant (SCT) was applied and complete response was achieved. The second case represents an example of d'emblee transformation of intrafollicular neoplasia to CD30-positive large B cell lymphoma. Immunoglobulin K deleting element (IgKde) and cytogenetic identity between both phases was demonstrated. The patient was in partial response after four cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).
Conclusions:
CD30 expression was found to be associated in these cases to the transformation event and could be considered a therapeutic target to add to conventional immunochemotherapeutic regimens, even in combination with auto-SCT. We suggest looking for CD30 expression in transformed follicular lymphoma cases.
More Related Videos
07:39Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
06:20Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
Published on: January 12, 2024