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Lactococcus lactis subsp. lactis JCM 5805 activates natural killer cells via dendritic cells

Hiroaki Suzuki1, Konomi Ohshio1, Daisuke Fujiwara1

  • 1a Central Laboratories for Key Technologies , Kirin Co., Ltd. , Yokohama , Japan.

Bioscience, Biotechnology, and Biochemistry
|December 2, 2015
PubMed

Insights

Lactococcus lactis JCM 5805 (JCM5805) activates natural killer (NK) cells, including plasmacytoid dendritic cells (pDCs). Oral JCM5805 administration boosts NK cell cytotoxic activity, suggesting immune-enhancing potential.

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Lactococcus lactis subsp. lactis JCM 5805 (JCM5805) is known to stimulate plasmacytoid dendritic cells (pDCs).
  • Natural killer (NK) cells are crucial components of the innate immune system, involved in host defense against pathogens and tumors.

Purpose of the Study:

  • To investigate the effect of JCM5805 on NK cell activation.
  • To elucidate the role of dendritic cells, including pDCs, in JCM5805-mediated NK cell activation.
  • To assess the impact of oral JCM5805 administration on NK cell cytotoxic activity.

Main Methods:

  • In vitro co-culture experiments to assess NK cell activation by JCM5805.
  • Flow cytometry and functional assays to analyze NK cell and dendritic cell phenotypes and functions.
  • In vivo studies involving oral administration of JCM5805 to evaluate NK cell activity.

Main Results:

  • JCM5805 was found to activate NK cells in vitro, with dendritic cells, including pDCs, mediating this effect.
  • Oral administration of JCM5805 led to enhanced cytotoxic activity of NK cells in vivo.

Conclusions:

  • JCM5805 demonstrates immunomodulatory properties by activating NK cells, potentially through dendritic cell pathways.
  • Oral administration of JCM5805 may serve as a strategy to enhance innate immune responses via NK cell activation.

Keywords:
Lactococcus lactisdendritic cellsnatural killer cells

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