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Neurologic Complications of Common Variable Immunodeficiency
Jenna Thuc-Uyen Nguyen1, Ari Green2,3, Michael R Wilson2
1Division of Allergy and Immunology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, 94143, USA. jenna.nguyen@ucsf.edu.
Insights
Common variable immunodeficiency (CVID) can cause serious neurologic issues. Infections and inflammatory conditions are the most frequent causes of these rare CVID-related neurological complications.
Area of Science:
- Immunology
- Neurology
Background:
- Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia, impaired B-cell differentiation, and recurrent infections.
- Neurologic complications are infrequent but recognized manifestations of CVID, encompassing a spectrum of disorders.
Observation:
- This article presents a case of CVID with significant neurologic morbidity.
- A review of existing literature categorizes the range of neurologic complications associated with CVID.
Findings:
- The case underscores the complex and varied neurologic presentations in CVID patients.
- Analysis of the current literature indicates that infections and inflammatory neurologic disorders are the predominant causes of neurologic manifestations in CVID.
Implications:
- Understanding the spectrum of neurologic complications in CVID is crucial for timely diagnosis and management.
- Further research into the pathogenesis of CVID-associated neurologic disorders may lead to improved therapeutic strategies.
Abstract:
Common variable immunodeficiency is a rare disorder of immunity associated with a myriad of clinical manifestations including recurrent infections, autoimmunity, and malignancy. Though rare, neurologic complications have been described in a small number of case reports and case series of CVID patients. In this article, we present a patient with CVID who suffered significant neurologic morbidity and categorize the reported range of neurologic complications associated with CVID. Our case highlights the complex nature of neurologic manifestations in CVID patients, and our review of the current database suggests that infection and inflammatory neurologic disorders are the cause of most neurologic presentations.
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