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Expression pattern of programmed death-1 in lymphocyte-rich classical Hodgkin lymphoma according to the growth

Jai Hyang Go1

  • 1Department of Pathology, Dankook University College of Medicine, Cheonan, Chungnam, Korea.

Indian Journal of Pathology & Microbiology
|October 11, 2016
PubMed

Insights

This study details a rare case of lymphocyte-rich classical Hodgkin lymphoma (LRCHL). Programmed death-1 (PD-1) expression varied significantly between nodular and interfollicular areas in tumor cells.

Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • Lymphocyte-rich classical Hodgkin lymphoma (LRCHL) is a rare subtype of Hodgkin lymphoma.
  • Programmed death-1 (PD-1) is an immune checkpoint receptor expressed on T cells, and its role in LRCHL is not fully understood.
  • Understanding PD-1 expression patterns can provide insights into tumor microenvironment and potential therapeutic targets.

Observation:

  • A 57-year-old male presented with enlarged neck lymph nodes.
  • Histopathology confirmed LRCHL with distinct nodular and interfollicular patterns.
  • Immunohistochemistry revealed sparse, weakly PD-1 positive cells in interfollicular areas.

Findings:

  • A significant increase in the number and staining intensity of PD-1 positive cells was observed in the nodular areas.
  • These PD-1 positive cells formed rosettes around the tumor cells within the nodular regions.
  • This differential expression suggests a localized immune response within the tumor microenvironment.

Implications:

  • The distinct PD-1 expression patterns may influence the efficacy of PD-1 blockade therapies in LRCHL.
  • Further research is warranted to elucidate the functional role of PD-1 positive cells in different compartments of LRCHL.
  • This case highlights the importance of detailed spatial analysis of immune markers in lymphoma subtyping and treatment strategy.

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