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Updated: Mar 12, 2026

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
A "Vanishing", Tuberculous, Pericardial Effusion
Jacques Liebenberg1, Pieter van der Bijl2
1Department of Internal Medicine, Kimberley Provincial Hospital, Du Toitspan Road, Kimberley Hospital, Kimberley, South Africa.
Insights
A rare complication of pericardiocentesis, a pleuro-pericardial connection, can occur after draining large tuberculous pericardial effusions. Recognizing this iatrogenic injury prevents further harm to the heart and coronary arteries during aspiration attempts.
Area of Science:
- Cardiology
- Thoracic Surgery
- Infectious Diseases
Background:
- Pericardiocentesis is a procedure to drain fluid from the pericardial sac.
- Tuberculous pericardial effusion can lead to large fluid accumulation.
- Iatrogenic complications can arise from invasive procedures.
Purpose of the Study:
- To describe an iatrogenic pleuro-pericardial connection.
- To highlight the importance of recognizing this complication after pericardiocentesis.
- To prevent further injury during aspiration attempts.
Main Methods:
- Case presentation of a patient with tuberculous pericardial effusion.
- Description of pericardiocentesis procedure.
- Analysis of the resulting pleuro-pericardial connection.
Main Results:
- An iatrogenic connection between the pleura and pericardium was identified.
- This complication occurred after pericardiocentesis for a large tuberculous effusion.
- Failure to aspirate fluid post-initial puncture indicated the complication.
Conclusions:
- Pleuro-pericardial connection is a potential iatrogenic complication of pericardiocentesis.
- Clinical awareness is crucial for prompt diagnosis.
- Early recognition prevents myocardial and coronary artery injury.
Abstract:
We present an iatrogenic, pleuro-pericardial connection resulting from pericardiocentesis of a large, tuberculous, pericardial effusion. Recognition of this situation is paramount when one is unable to aspirate pericardial fluid after a successful, initial puncture. Such knowledge will help prevent myocardial or coronary artery injury with further attempts at aspiration.
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