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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
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A novel HLA-C allele, HLA-C*08:128, was identified in a leukemia patient by polymerase chain reaction sequence-based
W Zhang1,2,3, S-D Tao1,2,3, Z-D Han1,2,3
1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
HLA
|February 7, 2017
Insights
The human leukocyte antigen (HLA) -C*08:128 allele differs from HLA-C*08:01:01 by a single nucleotide polymorphism at position 704. This finding contributes to understanding HLA allele diversity.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The human leukocyte antigen (HLA) system is crucial for immune response.
- Specific HLA alleles are associated with various diseases and drug reactions.
- Detailed characterization of novel HLA alleles is essential for understanding immune system variations.
Purpose of the Study:
- To describe the molecular differences between the novel HLA-C*08:128 allele and a known reference allele.
Main Methods:
- Sequence analysis of the HLA-C gene.
- Comparison of nucleotide sequences between HLA-C*08:128 and HLA-C*08:01:01.
Main Results:
- A single nucleotide substitution (C to T) was identified at position 704 in HLA-C*08:128 compared to HLA-C*08:01:01.
- This substitution results in a distinct genetic profile for the HLA-C*08:128 allele.
Conclusions:
- HLA-C*08:128 represents a newly identified variant within the HLA-C locus.
- This molecular characterization adds to the known repertoire of HLA alleles.
Abstract:
HLA-C*08:128 shows a substitution C to T at position 704 when compared to HLA-C*08:01:01.
