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A novel HLA-B allele: HLA-B*40:241

J W Zheng1, W Shen1, Y Sun1

  • 1Blood Typing Laboratory, Shanghai Blood Center, Shanghai, China.

HLA
|December 27, 2017
PubMed

Insights

A novel Human Leukocyte Antigen (HLA)-B allele, HLA-B*40:241, has been identified. This new allele is distinguished from HLA-B*40:01:01 by a single nucleotide substitution.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Human Leukocyte Antigen (HLA) System

Background:

  • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response.
  • Genetic variations within HLA alleles are significant for transplantation and disease association studies.
  • Accurate HLA allele identification is essential for personalized medicine.

Purpose of the Study:

  • To report the discovery and initial characterization of a new HLA-B allele.
  • To provide detailed information on the genetic variation distinguishing this novel allele from known alleles.

Main Methods:

  • High-resolution HLA typing methodologies were employed.
  • Sequence analysis was performed to identify nucleotide differences.

Main Results:

  • A novel HLA-B allele, designated HLA-B*40:241, was identified.
  • This allele differs from the known HLA-B*40:01:01 allele by a single nucleotide substitution at position 691.

Conclusions:

  • The identification of HLA-B*40:241 expands the known HLA-B allele repertoire.
  • This finding contributes to the ongoing efforts in high-resolution HLA typing and population genetics.

Keywords:
HLA-B*40:241new allelesequence-based typing

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