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Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell

Vanessa Szablewski1, Valérie Costes-Martineau1, Céline René2

  • 1Département de Pathologie, CHU Montpellier, Montpellier, France.

Journal of Cutaneous Pathology
|June 1, 2018
PubMed

Insights

This report details a rare composite lymphoma (CL) case involving two distinct lymphomas simultaneously. It describes a unique co-occurrence of primary cutaneous large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma.

Area of Science:

  • Hematology
  • Dermatopathology
  • Oncology

Background:

  • Composite lymphoma (CL) is characterized by the simultaneous presence of two distinct lymphoma types in one tissue.
  • Immunoglobulin M monoclonal gammopathy of undetermined significance can be a precursor or co-occurring condition.

Observation:

  • An 89-year-old male presented with a cutaneous eruption of nodules.
  • Excisional biopsy revealed dual cutaneous infiltration: large B-cells (CD20+/MUM1+/BCL2+) and a T-cell component (CD3+/CD8+/granzyme B+/TCRβF1+) in the subcutaneous fat.

Findings:

  • The patient was diagnosed with composite lymphoma, specifically primary cutaneous large B-cell lymphoma-leg type (PCLBCL-leg type) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL).
  • This represents the first documented case of coexistent PCLBCL-leg type and SPTCL.

Implications:

  • This case expands the understanding of rare composite lymphoma presentations.
  • Highlights the importance of thorough histopathological and immunophenotypic analysis for diagnosing complex cutaneous lymphomas.
  • Contributes to the literature on rare lymphoma subtypes and their combinations.

Keywords:
composite lymphomaprimary cutaneous large B-cell lymphoma-leg typesubcutaneous panniculitis-like T-cell lymphoma

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