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Epithelial expression of the hormone leptin by bovine skin

Francesca Mercati1, Cecilia Dall'Aglio, Ludovica Timperi

  • 1University of Perugia, Department of Veterinary Medicine. francesca.mercati@unipg.it.

European Journal of Histochemistry : EJH
|January 18, 2019
PubMed

Insights

Leptin (Lep) in bovine skin regulates epidermis growth and hair follicle cycling. This study found Lep and its receptor (LepR) in the epidermis and hair follicles, independent of intradermal fat.

Area of Science:

  • Dermatology
  • Endocrinology
  • Veterinary Science

Background:

  • Leptin (Lep) is known to influence skin functions like keratinocyte proliferation, wound healing, and hair follicle development in various species.
  • While Lep is secreted by skin structures and intradermal adipose tissue, its role in bovine skin remains uninvestigated.

Purpose of the Study:

  • To investigate the expression of Leptin (Lep) and its receptor (LepR) in bovine skin.
  • To determine the presence and extent of intradermal adipose tissue in bovine skin.

Main Methods:

  • Morphological evaluation of bovine skin.
  • Analysis of Lep and LepR presence and localization using RT-PCR and immunohistochemistry.

Main Results:

  • Bovine skin exhibits a thick dermis lacking adipocytes, with hair follicles, sebaceous, and sweat glands located superficially.
  • RT-PCR confirmed the presence of Lep and LepR transcripts.
  • Immunohistochemistry revealed Lep and LepR expression in the epidermis and hair follicles.

Conclusions:

  • In bovine skin, Leptin (Lep) likely controls epidermis growth and hair follicle cycling via paracrine and autocrine mechanisms.
  • The absence of intradermal adipose tissue suggests Lep's function is independent of this fat source in bovines.

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