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Antigen presentation by dendritic cells for B cell activation

William R Heath1, Yu Kato1, Thiago M Steiner1

  • 1Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, 3010, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Victoria, 3010, Australia.

Current Opinion in Immunology
|May 10, 2019
PubMed

Insights

Conventional dendritic cells (cDC), particularly type 2 cDC (cDC2), play a key role in activating B cells with native antigens. Understanding this function is vital for developing better humoral vaccines.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • B cell activation relies on antigen presentation, primarily by follicular dendritic cells (FDCs) and CD169+ macrophages.
  • Conventional dendritic cells (cDCs) are known for T cell priming but their role in B cell activation is less understood.

Purpose of the Study:

  • To investigate the underappreciated role of conventional dendritic cells (cDCs) in native antigen presentation to B cells.
  • To identify which subsets of cDCs are involved in B cell priming.

Main Methods:

  • The study reviews existing evidence on antigen presentation pathways to B cells.
  • Focuses on the mechanisms by which cDCs interact with B cells.

Main Results:

  • Conventional dendritic cells (cDCs), especially type 2 cDCs (cDC2), can present native antigens to B cells.
  • Type 1 cDCs (cDC1) may also contribute to this process.
  • This function of cDCs is distinct from their role in T cell priming.

Conclusions:

  • Conventional dendritic cells (cDCs) are important, yet overlooked, players in B cell activation.
  • Further research into cDC-mediated B cell priming could lead to improved vaccine strategies for humoral immunity.

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