Related Experiment Video

Updated: Jan 23, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

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IFN-γ: A cytokine at the right time, is in the right place

J Daniel Burke1, Howard A Young2

  • 1AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Seminars in Immunology
|June 22, 2019
PubMed

Insights

Interferon gamma (IFN-γ) is crucial for anti-tumor immunity. This review explores how IFN-γ overcomes tumor-induced immunosuppression and discusses strategies to enhance immunotherapy by modulating the tumor microenvironment.

Area of Science:

  • Immunology
  • Cancer Research
  • Oncology

Background:

  • Interferon gamma (IFN-γ) is a key cytokine in tumor immunity.
  • The tumor microenvironment's complexity impacts immunotherapy efficacy.
  • IFN-γ and related factors predict immunotherapy success.

Purpose of the Study:

  • To review the immunosuppressive barriers IFN-γ faces in eliminating tumors.
  • To explore strategies for modulating immune responses to favor tumor rejection.

Main Methods:

  • Literature review of existing research on IFN-γ and tumor immunity.
  • Analysis of cellular interactions within the tumor microenvironment.
  • Discussion of current immunotherapy approaches and their relation to IFN-γ.

Main Results:

  • IFN-γ must overcome multiple immunosuppressive mechanisms within the tumor.
  • Checkpoint inhibitors have improved cancer treatment outcomes.
  • IFN-γ remains a strong predictor of successful cancer immunotherapy.

Conclusions:

  • Understanding IFN-γ's role is vital for improving cancer immunotherapy.
  • Targeting immunosuppressive barriers can enhance anti-tumor immune responses.
  • Modulating the immune system in favor of tumor rejection is a promising therapeutic avenue.

Keywords:
IL-12ImmunosuppressionImmunotherapyInterferon gammaTumor microenvironment

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