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Regulation of B-cell function by NF-kappaB c-Rel in health and disease

Shrikanth C Basavarajappa1, Parameswaran Ramakrishnan2,3,4

  • 1Department of Pathology, School of Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, 6526, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA.

Cellular and Molecular Life Sciences : CMLS
|March 5, 2020
PubMed

Insights

The transcription factor c-Rel is crucial for B-cell functions like survival and antibody production. Its dysregulation is linked to lymphomas and autoimmune diseases, making it a potential therapeutic target.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • B cells are key players in humoral immunity and regulate cellular immunity.
  • Nuclear Factor kappaB (NF-κB) transcription factors are critical regulators of B-cell functions.
  • The NF-κB subunit c-Rel is vital for B-cell survival, proliferation, and antibody production.

Purpose of the Study:

  • To review the diverse roles of c-Rel in normal B-cell biology.
  • To explore the involvement of c-Rel in B-cell-associated pathologies.
  • To assess c-Rel as a potential prognostic and therapeutic target in B-cell diseases.

Main Methods:

  • Literature review of studies on c-Rel function in B cells.
  • Analysis of data linking c-Rel dysregulation to B-cell homeostasis.
  • Examination of evidence supporting c-Rel as a therapeutic target.

Main Results:

  • c-Rel is essential for B-cell survival, proliferation, and antibody production.
  • Altered c-Rel expression or activation contributes to B-cell lymphomas and autoimmune diseases.
  • c-Rel's critical roles highlight its potential as a prognostic marker and therapeutic target.

Conclusions:

  • c-Rel plays a multifaceted role in B-cell function and homeostasis.
  • Dysregulation of c-Rel is implicated in significant B-cell pathologies.
  • Targeting c-Rel offers a promising strategy for managing B-cell lymphomas and autoimmune conditions.

Keywords:
Antibody productionAutoimmunityB lymphocytesLymphomaTranscription

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