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Updated: Aug 8, 2026
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Case report: multimodality imaging to diagnose cardiac diffuse large B-cell lymphoma
Yahya E Alansari1, Brian Yudhistiara2, René P Michel3
1Division of Cardiology, Department of Medicine, McGill University, 1009 rue de Bleury, Apt 1009, Montréal, QC H2Z 0A3, Canada.
Insights
Primary cardiac lymphoma (PCL) is rare, often delaying diagnosis. This case highlights that prompt diagnosis and R-CHOP chemotherapy can lead to complete remission in PCL patients.
Area of Science:
- Cardiology
- Oncology
- Hematology
Background:
- Primary cardiac lymphoma (PCL) is an exceptionally rare malignancy.
- PCL often presents with nonspecific symptoms, complicating early diagnosis.
Observation:
- An 81-year-old male presented with PCL involving the right atrium, right ventricular outflow tract, and pulmonary artery.
- Positron emission tomography-computed tomography (PET-CT) revealed concurrent liver and lung metastases.
Findings:
- Biopsy confirmed diffuse large B-cell lymphoma as the PCL type.
- The patient achieved complete remission following R-CHOP chemotherapy.
Implications:
- Timely diagnosis is crucial for improving outcomes in PCL.
- Aggressive chemotherapy regimens like R-CHOP can be effective even in advanced PCL cases.
Background:
Primary cardiac lymphoma (PCL) is rare and can present with a wide variety of clinical symptoms, frequently leading to a delay in diagnosis.
Case Summary:
We report a case of a PCL in an 81-year-old man. Cardiac magnetic resonance imaging showed multiple masses in the right atrium and a mass in the right ventricular outflow tract extending to the pulmonary artery. Biopsy revealed a diffuse large B-cell lymphoma. The patient also had metastases to the liver and lung on the positron emission tomography-computed tomography (PET-CT) scan. He was treated with R-CHOP chemotherapy, with complete remission documented PET-CT scans.
Conclusion:
Although most patients with PCL die before chemotherapy can be initiated, a timely diagnosis can result in a favourable outcome.
