Related Experiment Video

Updated: Sep 25, 2025

Culture of myeloid dendritic cells from bone marrow precursors
06:39

Culture of myeloid dendritic cells from bone marrow precursors

Published on: July 25, 2008

22.7K

Blastic Indeterminate Dendritic Cell Tumor Associated With Chronic Myelomonocytic Leukemia

Austin Ellis1, Ismail Elbaz Younes, Haipeng Shao

  • 1Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

The American Journal of Dermatopathology
|April 27, 2022
PubMed

Insights

Blastic indeterminate dendritic cell tumor (BIDCT) is a rare cancer linked to chronic myelomonocytic leukemia (CMML). BIDCT associated with CMML may indicate a poorer prognosis compared to IDCT without CMML.

Area of Science:

  • Oncology
  • Hematology
  • Dermatopathology

Background:

  • Indeterminate dendritic cell tumor (IDCT) is a rare neoplasm.
  • IDCT can be associated with hematologic malignancies.
  • Chronic myelomonocytic leukemia (CMML) is a type of blood cancer.

Observation:

  • A case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) is presented in a 75-year-old man with CMML.
  • The BIDCT exhibited blastic histiocytoid morphology, with CD1a and S100 positivity, and lacked langerin expression.
  • This case is part of a literature review of 11 reported cases of IDCT/BIDCT associated with CMML.

Findings:

  • The study summarizes clinicopathological characteristics of IDCT/BIDCT associated with CMML.
  • Clonal relationship between IDCT and CMML cells was observed in 4 tested cases.
  • Patients with IDCT/BIDCT and CMML appear to have worse clinical outcomes than those with IDCT alone.

Implications:

  • This research highlights the association between rare dendritic cell neoplasms and myeloid malignancies.
  • Understanding the clinicopathological features and outcomes is crucial for patient management.
  • Further research may elucidate the pathogenetic mechanisms and improve therapeutic strategies for these complex cases.

More Related Videos

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model08:00

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

20.5K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.2K

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K