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Acute severe thrombocytopenia following iodinated radiographic contrast medium infusion: a case report

Baraa M M Sharawi1, Bahaa M Bashir2, Abdallah Al-Tell2

  • 1Departments of Internal Medicine.

Annals of Medicine and Surgery (2012)
|February 27, 2023
PubMed

Insights

Acute contrast-induced thrombocytopenia is a rare complication of iodinated contrast media. This case highlights a severe reaction, emphasizing the need for supportive care and further research into its mechanisms.

Area of Science:

  • Radiology
  • Hematology
  • Pharmacology

Background:

  • Acute contrast-induced thrombocytopenia is an uncommon complication.
  • Modern low-osmolarity iodinated contrast media are associated with rare instances of this condition.
  • Few reports exist in English literature.

Purpose of the Study:

  • To report a case of severe, life-threatening thrombocytopenia following intravenous contrast medium administration.
  • To discuss the management and potential mechanisms of contrast-induced thrombocytopenia.

Main Methods:

  • Case presentation of a 79-year-old male patient.
  • Monitoring of platelet count following contrast infusion.
  • Treatment with corticosteroids and platelet transfusion.

Main Results:

  • Patient developed severe thrombocytopenia (platelet count dropped to 2×109/l) within 1 hour of contrast infusion.
  • Platelet count gradually normalized within days following treatment.
  • Corticosteroid administration and platelet transfusion were part of the supportive care.

Conclusions:

  • Iodinated contrast-induced thrombocytopenia is a rare complication with an unclear causative mechanism.
  • While platelet counts often normalize spontaneously, supportive treatment is crucial.
  • Corticosteroids are frequently used, but further studies are needed to understand the exact mechanism.

Keywords:
case reportiodinated contrast mediumthrombocytopenia

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