[Lugol as a rare cause of anaphylactic reaction after colposcopy. Case report]

Area of Science:

• Gynecology
• Allergy and Immunology

Background:

• Lugol solution, a mixture of elemental iodine and potassium iodide, is utilized in colposcopy for detecting cervical cell abnormalities.
• Cervical cancer screening often involves colposcopy, a procedure that may use Lugol solution as a diagnostic aid.

Observation:

• A 31-year-old female developed anaphylaxis 90 minutes after a colposcopy where Lugol solution and acetic acid were applied.
• Skin prick testing with Lugol solution yielded a positive result, indicating a potential allergy.
• Intradermal testing confirmed sensitivity to Lugol solution and elemental iodine, while cross-reactivity with other iodine preparations was ruled out.

Findings:

• The case report details a rare instance of anaphylaxis attributed to Lugol solution following a colposcopy.
• Positive skin and intradermal tests confirmed allergy to Lugol solution.
• The patient demonstrated tolerance to alternative iodine-containing preparations and potassium iodide.

Implications:

• This case highlights the possibility of Lugol solution-induced anaphylaxis, a rare but serious adverse reaction.
• Awareness of this potential allergy is crucial for gynecologists and allergists during colposcopic procedures.
• Further investigation into iodine-based contrast media allergies may be warranted.