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Updated: Jul 12, 2026
The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
Published on: July 3, 2014
[Transbronchial lung cryobiopsy in interstitial lung diseases]
C Menigoz1, S Dirou1, C Sagan2
1Nantes Université, CHU Nantes, service de pneumologie, l'institut du thorax, Nantes, France.
Insights
Transbronchial lung cryobiopsy (TBLC) offers a minimally invasive approach for diagnosing interstitial lung disease (ILD) when CT scans and clinical data are insufficient. This procedure provides a high diagnostic yield with an acceptable safety profile, making it a valuable first-line option.
Area of Science:
- Pulmonology
- Interventional Pulmonology
- Diagnostic Pathology
Context:
- Interstitial lung disease (ILD) diagnosis can be challenging, often requiring invasive procedures.
- Multidisciplinary discussion (MDD) integrating clinical, imaging, and biological data may not yield a definitive diagnosis.
- Histological confirmation is sometimes necessary for accurate ILD assessment.
Purpose:
- To evaluate the diagnostic yield and safety of transbronchial lung cryobiopsy (TBLC) in patients with ILD.
- To compare TBLC with conventional forceps biopsy and surgical lung biopsy.
- To assess the role of TBLC in the diagnostic algorithm for ILD.
Summary:
- Transbronchial lung cryobiopsy (TBLC) is a minimally invasive bronchoscopic procedure for ILD diagnosis.
- TBLC provides larger tissue samples than conventional biopsies, improving diagnostic yield.
- The procedure has an acceptable risk profile, mainly pneumothorax and bleeding, and is safer than surgical lung biopsy.
- TBLC, decided during MDD, achieves an approximate 80% diagnostic yield.
- TBLC is proposed as a first-line diagnostic tool in experienced centers, with surgical biopsy as a second-line option.
Impact:
- TBLC enhances the diagnostic capabilities for ILD, potentially reducing the need for more invasive procedures.
- It offers a safer and more effective alternative to conventional biopsies for obtaining lung tissue.
- The findings support the integration of TBLC into the initial diagnostic work-up for selected ILD patients.
Abstract:
In some cases of interstitial lung disease (ILD), clinical and biological findings associated with CT scan pattern during multidisciplinary discussion (MDD) fail to yield a confident diagnosis. In these cases, histology may be necessary. Transbronchial lung cryobiopsy (TBLC) is a bronchoscopic procedure that has been developed in recent years and currently contributes to diagnostic work-up in patients with ILD. TBLC provides tissue samples for histological analysis with an acceptable risk of complications, consisting mainly in pneumothorax or bleeding. In addition to higher diagnostic yield than conventional forceps biopsies, the procedure shows a better safety profile than surgical biopsies. The indication to perform TBLC is decided during a 1st MDD and during a 2nd MDD, results can provide a diagnostic yield approximating 80%. TBLC appears to be an attractive, minimally invasive technique to be proposed as a first-line procedure in selected patients in experienced centers, while surgical lung biopsy may be considered as a second-line solution.
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